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Hence, the inhibition of such oxidation by zyloprim allopurinol may result in as much as a 75 reduction in the therapeutic dose requirement of mercaptopurine when the two compounds are given together.

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PregnancyAllopurinol is not recommended for women who are or may become pregnant unless the potential benefits outweigh the possible risksIf you are or may be pregnanttalk to your doctor about the risks and benefits of this medication.

The most frequent adverse reaction to Zyloprim is skin rashSkin reactions can be severe and sometimes fatalThereforetreatment with Zyloprim should be discontinued immediately if a rash developssee WARNINGSSome patients with the most severe reaction also had feverchillsarthralgiascholestatic jaundiceeosinophilia and mild leukocytosis or leukopeniaAmong 55 patients with gout treated with Zyloprim for 3 to 34 monthsaverage greater than 1 yearand followed prospectivelyRundles observed that 3of patients developed a type of drug reaction which was predominantly a pruritic maculopapular skin eruptionsometimes scaly or exfoliativeHoweverwith current usageskin reactions have been observed less frequently than 1The explanation for this decrease is not obviousThe incidence of skin rash may be increased in the presence of renal insufficiencyThe frequency of skin rash among patients receiving ampicillin or amoxicillin concurrently with Zyloprim has been reported to be increasedsee PRECAUTIONS

This list is not complete and other drugs may interact with ZyloprimTell your doctor about all medications you useThis includes prescriptionover-the-countervitaminand herbal productsDo not start a new medication without telling your doctor.

GastrointestinalDiarrheanauseaalkaline phosphatase increaseSGOT/SGPT increaseMetabolic and NutritionalAcute attacks of goutSkin and AppendagesRashmaculopapular rashEarly clinical studies and incidence rates from early clinical experience with Zyloprim suggested that these adverse reactions were found to occur at a rate of greater than 1The most frequent event observed was acute attacks of gout following the initiation of therapyAnalyses of current usage suggest that the incidence of these adverse reactions is now less than 1The explanation for this decrease has not been determinedbut it may be due to following recommended usagesee ADVERSE REACTIONS introductionINDICATIONS AND USAGEPRECAUTIONSand DOSAGE AND ADMINISTRATION

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