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Results showed that the onset of noticeable increased iris pigmentation occurred within the first year of treatment for the majority of the patients who developed noticeable increased iris pigmentationPatients continued to show signs of increasing iris pigmentation throughout the five years of the studyObservation of increased iris pigmentation did not affect the incidencenatureor severity of adverse eventsother than increased iris pigmentationrecorded in the studyIOP reduction was similar regardless of the development of increased iris pigmentation during the study.

Mixing eye drops containing thimerosal with latanoprost may cause precipitation of the chemicals within the dropsThereforethimerosal eye drops and latanoprost should be administered at least 5 minutes apartCombining latanoprost with other prostaglandin eye drops may reduce the effect of latanoprost and may even increase intraocular pressure.

Do not exceed recommended dosemay reduce efficacyOcular inflammationAphakiaPseudophakia with torn posterior lens capsuleRisk of macular edemaContact lensesremovemay reinsert lenses 15 minutes after administrationPregnancyCat.CNursing mothers.

Reactivation of Herpes Simplex keratitis has been reported during treatment with XALATANXALATAN should be used with caution in patients with a history of herpetic keratitisXALATAN should be avoided in cases of active herpes simplex keratitis because inflammation may be exacerbated.

Iris color change may not be noticeable for several months to yearsTypicallythe brown pigmentation around the pupil spreads concentrically towards the periphery of the iris and the entire iris or parts of the iris become more brownishNeither nevi nor freckles of the iris appear to be affected by treatmentWhile treatment with XALATAN can be continued in patients who develop noticeably increased iris pigmentationthese patients should be examined regularlysee PATIENT INFORMATION

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