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AGenerally acceptableControlled studies in pregnant women show no evidence of fetal risk.

In interaction studies in healthy volunteersRenagel had no effect on the bioavailability of digoxinwarfarinenalapril or metoprolol.

You should not take Renagel if you are allergic to sevelameror if you have a bowel obstruction.

Patients with chronic renal failure are predisposed to developing metabolic acidosisWorsening of acidosis has been reported upon switching from other phosphate binders to sevelamer in a number of studies where lower bicarbonate levels in the sevelamer-treated patients compared to patients treated with calcium-based binders were observedCloser monitoring of serum bicarbonate levels is therefore recommended.

Patients taking anti-arrhythmic medicinal products for the control of arrhythmias and anti-seizure medicinal products for the control of seizure disorders were excluded from clinical trialsCaution should be exercised when prescribing sevelamer hydrochloride to patients also taking these medicinal products.

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