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I went from premarin to estradiol years ago and get the same benefit from it.

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PREMARIN Vaginal Cream should not be used during lactationEstrogen administration to nursing women has been shown to decrease the quantity and quality of the breast milkDetectable amounts of estrogens have been identified in the breast milk of women receiving estrogen therapyCaution should be exercised when PREMARIN Vaginal Cream is administered to a nursing woman.

Before taking this medicationtell your doctor or pharmacist if you are allergic to itor if you have any other allergiesThis product may contain inactive ingredientswhich can cause allergic reactions or other problemsTalk to your pharmacist for more details.

Estrogens increase thyroid binding globulinTBGleading to increased circulating total thyroid hormoneas measured by protein-bound iodinePBIT4 levelsby column or by radio-immunoassayor T3 levelsby radio-immunoassayT3 resin uptake is decreasedreflecting the elevated TBGFree T4 and free T3 concentrations are unaltered.

You should not use Premarin if you haveundiagnosed vaginal bleedingliver diseasea bleeding disorderif you have major surgeryor if you have ever had a heart attacka strokea blood clotor cancer of the breastuterus/cervixor vagina.

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