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XELODA is indicated as a single agent for adjuvant treatment in patients with DukesC colon cancer who have undergone complete resection of the primary tumor when treatment with fluoropyrimidine therapy alone is preferredXELODA was non-inferior to 5-fluorouracil and leucovorin5-FU/LVfor disease-free survivalDFSPhysicians should consider results of combination chemotherapy trialswhich have shown improvement in DFS and OSwhen prescribing single-agent XELODA in the adjuvant treatment of DukesC colon cancerXELODA is indicated as first-line treatment of patients with metastatic colorectalcarcinoma when treatment with fluoropyrimidine therapy alone is preferredCombination chemotherapy has shown a survival benefit compared to 5-FU/LV aloneA survival benefit over 5-FU/LV has not been demonstrated with XELODA monotherapyUse of XELODA instead of 5-FU/LV in combinations has not been adequately studied to assure safety or preservation of the survival advantage.

Figure 3 Kaplan-Meier Curve for Overall Survival of Pooled DataStudies 1 and 2)

Have had heart problemshave kidney or liver problemshave been told that you lack the enzyme DPDdihydropyrimidine dehydrogenasehave any other medical conditionsare pregnant or plan to become pregnantXELODA can harm your unborn babyYou should not become pregnant during treatment with XELODATalk to your doctor about birth control choices that may be right for you during treatment with XELODAare breastfeeding or plan to breastfeedIt is not known if XELODA passes into your breast milkYou and your doctor should decide if you will take XELODA or breastfeedYou should not do both.

Figure 5 Kaplan-Meier Estimates of Survival XELODA and Docetaxel vs Docetaxel.

IWantGreatCare lets patients leave feedback on their experience of taking a particular drugThe feedback is from individual patientsIt is not informationor specialist medical advicefrom Cancer Research UK.

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