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If you also take cholestyramine, colesevelam, or colestipol space your doses apart in order to take vytorin either 2 hours before or 4 hours after you take any of these other medications.

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Ezetimibe and simvastatin can cause the breakdown of muscle tissuewhich can lead to kidney failureThis happens more often in womenin older adultsor in people who have kidney disease or poorly controlled hypothyroidismunderactive thyroid

Do not use Vytorin if you are pregnant or if you could become pregnantUse effective birth control.

Some side effects of ezetimibesimvastatin may occur that usually do not need medical attentionThese side effects may go away during treatment as your body adjusts to the medicineAlsoyour health care professional may be able to tell you about ways to prevent or reduce some of these side effectsCheck with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Unexplained muscle paintendernessor weaknessfeverunusual tirednessand dark colored urineswellingweight gainurinating less than usual or not at allchest paindry coughwheezingfeeling short of breathsevere pain in your upper.

Avoid eating grapefruit or drinking grapefruit juice while using this medication unless your doctor instructs you otherwiseGrapefruit can increase the amount of this medication in your bloodstreamConsult your doctor or pharmacist for more details.

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no specific treatment of overdosage with vytorin can be recommended.