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Symptoms of lioresal intrathecal overdose were reported in a sensitive adult patient after receiving a 25 mcg intrathecal bolus.

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LIORESAL INTRATHECALbaclofen injectionis indicated for use in the management of severe spasticityPatients should first respond to a screening dose of intrathecal baclofen prior to consideration for long term infusion via an implantable pumpFor spasticity of spinal cord originchronic infusion of LIORESAL INTRATHECAL via an implantable pump should be reserved for patients unresponsive to oral baclofen therapyor those who experience intolerable CNS side effects at effective dosesPatients with spasticity due to traumatic brain injury should wait at least one year after the injury before consideration of long term intrathecal baclofen therapyLIORESAL INTRATHECAL is intended for use by the intrathecal route in single bolus test dosesvia spinal catheter or lumbar punctureandfor chronic useonly in implantable pumps approved by the FDA specifically for the administration of LIORESAL INTRATHECAL into the intrathecal space.

In the alert patientempty the stomach promptly by induced emesis followed by lavageIn the obtunded patientsecure the airway with a cuffed endotracheal tube before beginning lavagedo not induce emesisMaintain adequate respiratory exchangedo not use respiratory stimulants.

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Baclofen is used to treat muscle spasms caused by certain conditionssuch as multiple sclerosisspinal cord injury/diseaseIt works by helping to relax the muscles.

Reservoir refilling must be performed by fully trained and qualified personnel following the directions provided by the pump manufacturerInadvertent injection into the subcutaneous tissue can occur if the reservoir refill septum is not properly accessedSubcutaneous injection may result in symptoms of a systemic overdose or early depletion of the reservoirRefill intervals should be carefully calculated to prevent depletion of the reservoiras this would result in the return of severe spasticity and possibly symptoms of withdrawal.

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