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Get medical help right away if you have any very serious side effectsincludingchest/jaw/left arm painfaintingfast/irregular heartbeatseizureseye pain/swelling/rednesswidened pupilsvision changessuch as seeing rainbows around lights at night

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Ask your doctor before taking a nonsteroidal anti-inflammatory drugNSAIDfor painarthritisfeveror swellingThis includes aspirinibuprofenAdvilMotrinnaproxenAlevecelecoxibCelebrexdiclofenacindomethacinmeloxicamand othersUsing an NSAID with this medicine may cause you to bruise or bleed easily.

In vitro drug metabolism studies suggest that there is a potential for drug interactions when trazodone is given with CYP3A4 inhibitorsRitonavira potent CYP3A4 inhibitorincreased the C maxAUCand elimination half-lifeand decreased clearance of trazodone after administration of ritonavir twice daily for 2 daysAdverse effects including nauseahypotensionand syncope were observed when ritonavir and trazodone were co-administeredIt is likely that ketoconazoleindinavirand other CYP3A4 inhibitors such as itraconazole or nefazodone may lead to substantial increases in trazodone plasma concentrationswith the potential for adverse effectsIf trazodone is used with a potent CYP3A4 inhibitora lower dose of trazodone should be considered.

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