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Since this drug can be absorbed through the skin and lungs and may harm an unborn babywomen who are pregnant or who may become pregnant should not handle this medication or breathe dust from the tablets or capsules.

Special attention to the possible development of toxicity should be exercised in patients being treated with cyclophosphamide if any of the following conditions are present.

General Disorders and Administrative Site Conditionsmultiorgan failuregeneral physical deteriorationinfluenza-like illnessinjection/infusion site reactionsthrombosisnecrosisphlebitisinflammationpainswellingerythemapyrexiaedemachest painmucosal inflammationastheniapainchillsfatiguemalaiseheadache.

To minimize bladder toxicityincrease normal fluid intake during and for 1-2 days after cyclophosphamide therapymost adult patients will require fluid intake of at least 2 L/dayhigh-dose regimens should be accompanied by vigorous hydration with or without mesna therapy.

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