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Azotaemia may be precipitated or increased by hydrochlorothiazideCumulative effects of the drug may develop in patients with impaired renal functionIf increasing azotaemia and oliguria develop during treatment of renal diseaseModureticshould be discontinued.

Neither potassium supplements nor a potassium-rich diet should be used withModureticexcept under careful monitoring in severe and/or refractory cases of hypokalaemia.

Hydrochlorothiazide should not be used for essential hypertension in pregnant women except in rare situations where no other treatment could be used.

You should not use this medication if you are allergic to hydrochlorothiazide or amilorideor if you have:

There is limited experience with hydrochlorothiazide during pregnancyespecially during the first trimesterAnimal studies are insufficientHydrochlorothiazide crosses the placentaBased on the pharmacological mechanism of action of hydrochlorothiazide its use during the second and third trimester may compromise foeto-placental perfusion and may cause foetal and neonatal effects like icterusdisturbance of electrolyte balancebone marrow depression and thrombocytopenia.

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