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antipsychotics eg, haloperidol, risperidone , corticosteroids eg, prednisone , insulin or oral medicines to treat diabetes eg, glipizide , theophylline, tricyclic antidepressants eg, amitriptyline , or other medicine that contains bupron sr because the risk of seizures may be increased nicotine replacement therapy eg, nicotine patches because the risk of high blood pressure may be increased amantadine, clopidogrel, cyclophosphamide, fluvoxamine, levodopa, linezolid, maois eg, phenelzine , nelfinavir, orphenadrine, or ticlopidine because they may increase the risk of bupropion s side effects carbamazepine, efavirenz, lopinavir, phenobarbital, phenytoin, rifamycins eg, rifampin , or ritonavir because they may decrease bupropion s effectiveness antiarrhythmics eg, flecainide, propafenone , beta-blockers eg, metoprolol , lorcaserin, phenothiazines eg, thioridazine , pimozide, selective serotonin reuptake inhibitors ssris eg, fluoxetine , tricyclic antidepressants eg, nortriptyline , or venlafaxine because the risk of their side effects may be increased by bupropion tamoxifen because its effectiveness may be decreased by bupron sr, which may lead to an increased risk of breast cancer recurrence in women with a history of breast cancer.

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anecdotal reports indicate bupropion may lower inflammatory mediators such as tumor necrosis factor-alpha, may lower fatigue in cancer and may help reduce concentration problems.

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