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Do not use any other medicines containing metformin or glibenclamide, in the form of either a single or a combination product, while you are being treated with glucovance.

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Rarelytoo much metformin can build up in the body and cause a serioussometimes fatalcondition called lactic acidosisLactic acidosis is more likely if you are an older adultif you have kidney or liver diseasedehydrationheart failureheavy alcohol useif you have surgeryif you have X-ray or scanning procedures that use iodinated contrastor if you are using certain drugsFor some conditionsyour doctor may tell you to stop taking this medication for a short timeAsk your doctor or pharmacist for more details.

Steps to reduce the risk of and manage metformin-associated lactic acidosis in these high risk groups are providedsee DOSAGE AND ADMINISTRATIONCONTRAINDICATIONSand PRECAUTIONS

The hypoglycemic action of sulfonylureas may be potentiated by certain drugsincluding nonsteroidal anti-inflammatory agents and other drugs that are highly protein boundsalicylatessulfonamideschloramphenicolprobenecidcoumarinsmonoamine oxidase inhibitorsand beta-adrenergic blocking agentsWhen such drugs are administered to a patient receiving Glucovancethe patient should be observed closely for hypoglycemiaWhen such drugs are withdrawn from a patient receiving Glucovancethe patient should be observed closely for loss of blood glucose control.

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