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When angiotensin II antagonists are administered simultaneously with NSAIDsi.eselective COX-2 inhibitorsacetylsalicylic acid at anti-inflammatory doses and non-selective NSAIDsattenuation of the antihypertensive effect may occurConcomitant use of angiotensin II antagonists or diuretics and NSAIDs may lead to an increased risk of worsening of renal functionincluding possible acute renal failureand an increase in serum potassiumespecially in patients with poor pre-existing renal functionThe combination should be administered with cautionespecially in the elderlyPatients should be adequately hydrated and consideration should be given to monitoring renal function after initiation of concomitant therapyand periodically thereafter.

Do not use Cozaar if you are pregnantIf you become pregnantstop taking this medicine and tell your doctor right awayLosartan can cause injury or death to the unborn baby if you take the medicine during your second or third trimester.

This medicinal product contains lactosePatients with rare hereditary problems of galactose intolerancethe Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine.

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advise female patients of childbearing age about the consequences of exposure to cozaar during pregnancy.