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Estrace should not be used by women who are or may be pregnant.

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Breast lumpspossible breast cancerask your doctor or health professional to show you how to examine your breasts monthly)

Estrogens may increase the risk of certain types of cancerincluding cancer of the breast or uterusIf you have or had cancertalk with your healthcare provider about whether you should take Estrace.

The Women’s Health InitiativeWHIestrogen-alone substudy reported increased risks of stroke and deep vein thrombosisDVTin postmenopausal women with daily oral conjugated estrogensCEaloneThe WHI estrogen-plus-progestin substudy reported increased risks of DVTpulmonary embolismstrokeand myocardial infarction in postmenopausal women with daily oral CE combined with medroxyprogesterone acetateMPAIn the absence of comparable datathese risks should be assumed to be similar for other dosage forms of estrogens.

The WHI estrogen-plus-progestin substudy demonstrated an increased risk of invasive breast cancer.

Using estrogens with or without progestins may increase your chances of getting heart attacksstrokesbreast cancerand blood clotsUsing estrogens with progestins may increase your risk of dementiaYou and your healthcare provider should talk regularly about whether you still need treatment with Estrace.

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