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Indinavir is metabolized by cyp3a4.

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Indinavir is used in combination with several other anti-HIV drugsusually nukesnucleoside analoguesand sometimes including drugs from other classes such as non-nukesnon-nucleoside reverse transcriptase inhibitorsCombinations such as this are called antiretroviral therapyor ARTFor more information on ARTsee CATIE’s Your Guide to HIV Treatment

Concomitant use of CRIXIVAN and StJohn’s wortHypericum perforatumor products containing StJohn’s wort is not recommendedCoadministration of CRIXIVAN and StJohn’s wort has been shown to substantially decrease indinavir concentrationssee CLINICAL PHARMACOLOGYDRUG INTERACTIONSand may lead to loss of virologic response and possible resistance to CRIXIVAN or to the class of protease inhibitors.

Patients should be informed that redistribution or accumulation of body fat may occur in patients receiving antiretroviral therapy and that the cause and long-term health effects of these conditions are not known at this time.

In both sets of studiesmilk thistle and vitamin Csubjects were taking indinavir as the sole PI in their regimenResults may be different when indinavir is taken in combination with other PIssuch as ritonavir.

If you miss a dose by less than 2 hourstake the missed dose as soon as you remember itHoweverif you miss a dose by more than 2 hoursskip the missed dose and continue your regular dosing scheduleDo not take a double dose to make up for a missed one.

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