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Because it appears in breast milkcaution should be exercised when LASIX is administered to a nursing mother.

Investigations into the mode of action of LASIX have utilized micropuncture studies in ratsstop flow experiments in dogs and various clearance studies in both humans and experimental animalsIt has been demonstrated that LASIX inhibits primarily the absorption of sodium and chloride not only in the proximal and distal tubules but also in the loop of HenleThe high degree of efficacy is largely due to the unique site of actionThe action on the distal tubule is independent of any inhibitory effect on carbonic anhydrase and aldosterone.

One study in six subjects demonstrated that the combination of furosemide and acetylsalicylic acid temporarily reduced creatinine clearance in patients with chronic renal insufficiencyThere are case reports of patients who developed increased BUNserum creatinine and serum potassium levelsand weight gain when furosemide was used in conjunction with NSAIDs.

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