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The concomitant use of procyclidine with some neuroleptics for the treatment of extrapyramidal symptoms has been associated with a reduction in neuroleptic plasma concentrationsHowever this reduction is unlikely to be associated with a significant reduction in clinical effect.

Patients who have been receiving other drugs may be transferred to procyclidine hydrochlorideThis is accomplished gradually by substituting 2.5 mg three times a day for all or part of the original drugThe dose of procyclidine is then increased as required while that of the other drug is correspondingly omitted or decreased until complete replacement is achievedThe total daily dosage may then be adjusted to the level which produces maximum benefit.

Exposure to high environmental temperature and humidity in association with a phenothiazine/anticholinergic drug regimen has rarely resulted in hyperpyrexia.

Take this medication regularly in order to get the most benefit from itTo help you remembertake it at the same times each day.

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