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In patients with advanced diseaseLetrozole therapy should continue until tumor progression is evident.

In patients with advanced diseaseLetrozole therapy should continue until tumor progression is evident.

Letrozole is a drug used as hormone therapy for the treatment of breast cancerand included in a group of drugs called aromatase inhibitors due to its mechanism of actionEstrogen and progesterone are female sex hormones that promote cancer growthWhile in menstruating womenthese hormones are produced in the ovariesin menopausal womenit is produced in the fat tissue through a process known as aromataseThereforeletrozole interferes with this process in order to decrease the levels of estrogen in the body andconsequentlystop or slow down cancer growthor decrease the probability of cancer recurrence after surgeryLetrozole is only effective in hormone sensitive or hormone receptor positive breast cancer and its use is limited to women after menopause.

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femara treatment in the first-line therapy of advanced breast cancer resulted in a median overall survival of 34 months compared with 30 months for tamoxifen logrank test p 0.